What is Hepatitis C?

  • Hepatitis C is a liver disease caused by the hepatitis C virus, the virus can cause both acute and chronic hepatitis infection, ranging in severity from a mild illness lasting a few weeks to a serious, lifelong illness.
  • The hepatitis C virus is a bloodborne virus and the most common modes of infection are through unsafe injection practices; inadequate sterilization of medical equipment; and the transfusion of unscreened blood and blood products.
  • 130–150 million people globally have chronic hepatitis C infection.
  • A significant number of those who are chronically infected will develop liver cirrhosis or liver cancer.

What is a Genotype?

  • Genotype is the term used to describe the specific genetic structure of hepatitis C. There are believed to be 6 major hepatitis C genotypes (1–6), each of which can be further subdivided into subtypes.
  • It is important to know your genotype because it can help your healthcare provider choose the right treatment for you. It can also affect the length of your treatment and your chance of being cured.

What is the Sofosbuvir/Daclatasvir Protocol?

  • The oral direct acting antiviral drugs, Daclatasvir and Sofosbuvir are considered safe and highly effective in the treatment of hepatitis C. The combination therapy worked well even in patients who are considered hard to treat.
  • The Sofosbuvir/Daclatasvir combination is considered a pan-genotypic combination, which means it is suitable for all 6 hepatitis C genotypes. The Sofosbuvir/Daclatasvir combination achieved high cure rates across all hepatitis C genotypes.

How do I take SOFOSBUVIR?

  • Dose: 1 tablet 400 mg daily, taken at the same time each day.
  •  You can take it with or without food.
  •  Store at room temperature away from sunlight.
  •  You should not take Sofosbuvir alone.

How do I take DACLATASVIR?

  • Dose: 1 tablet 60 mg daily, taken at the same time each day.
  •  You can take it with or without food.
  •  Store at room temperature away from sunlight.
  •  You should not take Daclatasvir alone.

What do I do if I missed a dose?

  • If you missed a dose of Sofosbuvir or Daclatasvir, TAKE THE MISSED DOSE THE SAME DAY as soon as you remember, take your next dose of Sofosbuvir or Daclatasvir at your regular time the next day.
  • Do not take more than 1 tablet of Sofosbuvir or Daclatasvir in a day.
  • Do not take 2 doses at the same time to make up for a missed dose.

What is SVR and how to find out if I am CURED?

  • SVR is defined as Sustained Viral Response and is considered a successful treatment outcome, meaning that hepatitis C is undetectable for 12 weeks after the end of treatment.
  • Cure is defined as reaching undetectable levels of Hepatitis C virus in the blood 3 months after treatment is completed.

What are the side effects of SOFOSBUVIR & DACLATASVIR?

  • The most common side effects of Sofosbuvir when used in combination with Daclatasvir Are: Headache, Fatigue, Nausea & Diarrhea.

Can I take the Sofosbuvir/Daclatasvir Protocol if I have Cirrhosis?

  • Yes, for most cases the Sofosbuvir/Daclatasvir Protocol can cure chronic hepatitis C if you have cirrhosis.

Can I take the Sofosbuvir/Daclatasvir Protocol if I failed with a previous treatment or was considered ineligible to take interferon?

  • Yes, if you were ineligible to take interferon or you failed to get cured with the Interferon-Ribavirin or the Telaprevir / Boceprevir Interferon-Ribavirin Triple Therapy, you still have a high change of getting cured with the Sofosbuvir/Daclatasvir Protocol.